International Stroke Conference 2019

Nursing Symposium & Pre-Con Symposia: Feb. 5, 2019
Sessions: Feb.6–8, 2019
Honolulu, Hawaii

Watch this space for ISC 2020 Registration


Abstract Submission
All abstract submissions are now closed for 2019


What's new for 2019

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Program at-a-Glance

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7:00 a.m. – 8:30 a.m.

New Roles for RNA in Stroke: It's Not Just about Protein Translation
Category: Experimental Mechanisms and Models

  • EV-derived ncRNAs in neuroprotection
  • IGF-1-induced neuroprotection via ncRNAs
  • The circular RNAome in ischemic stroke
  • Post-stroke Immune Targeting: Clinical Areas Including Noncoding RNAs as Biomarkers

Perspectives on vascular cognitive impairment and dementia
Category: Vascular Cognitive Impairment

  • Stroke, SVD and functional and cognitive decline
  • Risk factors and prevention strategies in VCID
  • CAA and VCID
  • Social activities and cognitive decline

Plasticity and the Promise of Recovery after Stroke: Novel, Practical and Clinical Considerations
Category: Clinical Rehabilitation and Recovery

  • Molecular mechanisms-are they important?
  • Changes in the CNS Leading to Recovery
  • Augmenting Plasticity Enhances Recovery?
  • Model of post-stroke motor recovery

The Changing Face of Subarachnoid Hemorrhage in the ICU
Category: SAH and Other Neurocritical Management

  • Poorgrade SAH- upward mobility in outcomes?
  • Advances n the management of cerebral vasospasm and DCI
  • The NINDS/ NCS Subarachnoid Hemorrhage Common Data Elements Project
  • Passing the baton in hemodynamic and fluid management of SAH: From Swan Ganz to bedside ultrasound

Oral Abstract Sessions

8:30 a.m. – 8:45 a.m.


8:45 a.m. – 10:15 a.m.

Big Picture on Intracerebral Hemorrhage: Practical Implications and Future Outlook
Category: Intracerebral Hemorrhage

  • Outcomes determinants considering modern stratification and hemorrhage expansion
  • Seal the leak: Blood pressure and procoagulants, promise and limitations
  • Intracranial pressure and cerebral perfusion: Impact in ICH?
  • Removing the clot and big picture future outlook

It’s Not “One Size Fits All”: Emerging Issues in Caregiving
Category: Nursing

  • CG Psychosocial/Demographic Determinants
  • Caregiver Characteristics and Engagement
  • Assessing CG Commitment and Capacity
  • Evidence-Based Stroke Care Transitions and Stroke TCM: Implementation Challenges
  • Improve Transitions Using Social Workers

Pericytes in Stroke: New Kids on the Block
Category: Basic and Preclinical Neuroscience of Stroke Recovery

  • Pericytes and transporter trafficking
  • Pericytes and cerebral blood flow
  • Imaging pericytes in vivo
  • Pericyte transdifferentiation in stroke

Small Vessel Disease: A Big Impact on Aged Society (an AHA/ASA and Japan Stroke Society Joint Symposium)
Category: Diagnosis of Stroke Etiology
  • Race, Ethnicity and Cerebral Small Vessel Diseases
  • Advanced Neuroimaging of Small Vessel Diseases
  • Medical Management for Small Vessel Diseases
  • Genetic Factors in Small Vessel Diseases

Oral Abstract Sessions

10:15 a.m. – 10:30 a.m.


10:30 a.m. – 12:00 Noon

Opening Main Event

  • Welcome from Nancy Brown, AHA’s CEO
  • Presidential Address, Ivor Benjamin, MD, FAHA
  • ISC Program Chair Welcome, Miguel Perez-Pinzon, PhD, FAHA
  • William M Feinberg Award Presentation and Lecture
  • Late-Breaking Science Oral Abstracts

12:10 p.m. – 1:30 p.m.

Fellow and Early Career Women in Stroke Mentoring Lunch

Advance Practice Providers Luncheon

1:30 p.m. – 2:30 p.m.

Blood Brain Barrier: Mechanisms and Opportunities for ICH
Category: Vascular Biology in Health and Disease

  • Pathways and Protection
  • Repair and Recovery
  • Clinical Trials and Translation
  • Translation Trials to Protect BBB after ICH

Functional Implications of Chronic Disorders for CBF Regulation and Stroke Outcome
Category: Vascular Biology in Health and Disease

  • Metabolic Syndrome and Secondary Thrombosis
  • Cerebral Blood Flow at the Microvascular Level
  • Hyperlipidemia and Perfusion Deficits
  • Cerebrovascular Dysfunction, Sex and Diabetes

I Know the Best Way to Select Patients and Perform Stroke Thrombectomy (Debate)
Category: Acute Endovascular Treatment

  • Always use perfusion imaging vs. Perfusion imaging is not needed
  • Direct to angio - no CT is needed
  • Do not use general anesthesia vs. Do use general anesthesia
  • Treat LVO patients with low NIHSS vs. Do not treat patients with low NIHSS

Town Hall Forum: Women in Stroke

Oral Abstract Sessions

2:30 p.m. – 3:00 p.m.


3:00 p.m. – 4:00 p.m.

CED Talks (Cerebrovascular Education and Discovery)

  • Title TBD – Patrick Lyden
  • Title TBD – Donna K Arnett
  • Forecast for a Brighter Future for Stroke Prevention – Ralph L Sacco

Cost Effective Stroke Interventions in Low and Middle Income Countries (an AHA/ASA and World Health Organization Joint Symposium)
Category: Community/Risk Factors

  • Global Burden of Stroke and its cost
  • The cost of stroke in South America
  • Acute treatment vs. prevention on budget
  • Convincing government of the global imperative for prevention

Post-stroke psychiatric symptoms
Category: Clinical Rehabilitation and Recovery

  • Depression
  • Apathy and delirium
  • Anger
  • Pharmacological Treatment

Telestroke Systems In the Endovascular Era – Extending the Extended Window (an AHA/ASA and American Academy of Neurology Joint Symposium)
Category: Emergency Care Systems

  • Telestroke As a Tool for Prehospital Triage
  • Telestroke as a Tool for Interfacility Endovascular Transfers
  • Multimodal Imaging in Telestroke Systems of Care
  • Endovascular Therapy In Resource Limited Countries - Can Telestroke Help?

Oral Abstract Sessions

4:00 p.m. – 4:15 p.m.


4:15 p.m. – 5:15 p.m.

Superwoman Syndrome: Racial/Ethnic Disparities in Stroke
Category: Nursing

  • Stroke Risk and Outcomes in Minority Women
  • RISE to Prevent Stroke in Black Women
  • Post-Stroke Needs of Minority Women
  • Family Caregiving in Minority Women

What do I do with this aneurysm?
Category: Aneurysm

  • What aneurysms should I treat?
  • What aneurysms should I leave alone?
  • Is there still a role for clipping?
  • Newer endovascular techniques for aneurysm therapy

What’s Old Is New Again: Neuroprotection for Stroke in 2019
Category: Acute Nonendovascular Treatment

  • Neuro-protection in the Pre-hospital Setting
  • Expanding Time Window for Thrombectomy: Neuro-protection in the Era of EVT
  • Preventing Reperfusion Injury: Neuro-protection after Acute Stroke Treatment
  • Vasculo-protection for Stroke

AIS Guidelines: Follow-up Session

Oral Abstract Sessions

5:15 pm – 5:30 pm


5:30 pm – 6:30 pm

Moderated Posters

6:30 pm – 7:00 pm


7:00 a.m. – 8:30 a.m.

Moya Moya Disease: What’s Behind the Smoke?
Category: Vascular Malformations

  • Evidence for Varying Disease Phenotypes: Phenotypical Differences among Various Populations - Insights from Epidemiology
  • Evidence for Varying Disease Phenotypes: Insights from Genetics
  • Deciding When to Intervene: Therapeutic Strategies for Long-term Patient Management
  • Deciding When to Intervene: BOLD Differences in Imaging Vascular Reactivity
  • Which Surgical Treatment Should Be Used for MMD? Indirect Bypasses Are Optimal Which Surgical Treatment Should Be Used for MMD? Direct Bypasses Are Best

Novel Approaches to Prehospital Stroke Care in the Endovascular Era - The Future Ain't What It Used To Be
Category: Emergency Care Systems

  • A Geospatial Approach to Stroke Systems of care in the Endovascular Era
  • Portable Brain Imaging in Prehospital Stroke Detection: Through the Looking Glass
  • Sensor Technology in Prehospital Stroke Detection: Scratching the Surface
  • Artificial Intelligence in Prehospital Stroke Detection: Automation in Motion

Vulnerable Carotid Plaque Imaging and Management: A New Dawn?
Category: Acute Neuroimaging

  • Ultrasound Imaging of carotid wall and plaque
  • CT and MR Imaging of carotid wall and plaque
  • Imaging of plaque inflammation and neovascularization
  • Low stenosis and high risk / High stenosis and low risk
  • Imaging of plaque regression and progression: impact of drug therapies

Oral Abstract Sessions

8:30 a.m. – 8:45 a.m.


8:45 a.m. – 10:15 a.m.

Medical therapy for symptomatic carotid stenosis: Time for modern data
Category: Cerebral Large Artery Disease

  • Multi-modal treatment for carotid stenosis
  • Genetic guidance for antiplatelet therapy
  • Do HTN targets matter?
  • Modern trials for symp carotid stenosis

Optimal timing for in-hospital initiation of secondary prevention therapies in Acute Ischemic Stroke
Category: In-hospital Treatment

  • Anticoagulation therapy for AF-related AIS
  • Statin therapy for AIS
  • Antihypertensive Medications for AIS
  • Carotid Revascularization Procedures for Symptomatic Carotid Stenosis

AIS Guidelines Q&A

Oral Abstract Sessions

10:15 a.m. – 10:30 a.m.


10:30 a.m. – 12:00 Noon

Thursday Main Event

  • David G Sherman Award Presentation Lecture
  • Late-Breaking Science Oral Abstracts

12:10 p.m. – 1:30 p.m.

Basic Science Networking Luncheon

Nursing and Rehabilitation Professionals Luncheon

1:30 p.m. – 2:30 p.m.

Looking into the Brain thru the Eye: re-examining the Retina as a Surrogate Marker for Cognitive Disorders
Category: Vascular Cognitive Impairment

  • Retinal microvascular analysis using fun
  • Retinal amyloid imaging: new method of
  • Retinal optical coherence tomography and
  • OCT-angiography: a promising tool to stu

Stroke, Anticoagulants and Antidotes
Category: Diagnosis of Stroke Etiology

  • DOACs: How Risky in Real Worlds?
  • Reversal Agents: How Developed?
  • ICH During Anticoagulation: How Managed?
  • Thrombolysis after Anticoagulant Reversal: Really Effective?

The Case of ISC vs Anti: Anti-platelets, Anti-thrombin, or Anti-Xa: What Is the Best “Anti” for My Patient?

Microbiome Session

Oral Abstract Sessions

3:00 p.m. – 4:00 p.m.

Bugher Foundation Update

  • Childhood Acute Ischemic Stroke Neuropsychological and Quality of Life Outcomes: Lesion-specific Plasticity in the Developing Brain
  • White Matter Stroke Repair: The Molecular Effects of Neurorehabilitation on Recovery
  • Exercise and Cognitive Training Post-stroke

Embolic Strokes of Undetermined Source in 2019
Category: Diagnosis of Stroke Etiology

  • RESPECT-ESUS vs. NAVIGATE-ESUS: What Have We Learned?
  • Updated evaluation of the ESUS concept
  • Do the results of the ESUS trials change
  • ESUS in the young

Paradigm Shifts and Better Models To Advance Cell-Based Therapies for Stroke
Category: Basic and Preclinical Neuroscience of Stroke Recovery

  • New Insights on Mechanistic Targets of Stem Cells
  • The Unique Advantages of Pig Stroke Models to Study Stem Cell Therapy Cell-based and Exosome Therapy
  • Clinical Trial Perspectives on Cell-based Therapies

Post-stroke Mood: A Treatable Factor Affecting Function and Return to Work
Category: Pediatric Stroke

  • Impact of Stroke upon Cognitive Outcome and Quality of Life: Are Children Different from Adults?
  • Mood Disorders Following Stroke in Children and Adolescents; Frequency and Impact
  • Prolonged Unemployment in Young Adult after Stroke: What Can We Modify?
  • Post-stroke Depression: What Are the Barriers to Care?

NIA/NINDS Session (Joint Government Agency Session)

Oral Abstract Sessions

4:15 p.m. – 5:15 p.m.

Novel targets for neuroprotection in stroke
Category: Experimental Mechanisms and Models

  • Spider venom for neuroprotection
  • AT2-receptor agonist nose-to-brain
  • GM6 - bench to bedside
  • Mas-receptor agonists for stroke

Salt and Sugar Intake with Increased Risk for Stroke and Vascular Health (an AHA/ASA and World Hypertension League Joint Symposium)
Category: Preventive Strategies

  • Stroke Risks and Salt/Sugar Intake
  • Hidden Salt and Sugar Sources in Diets
  • Populations at Greatest Risks from Salt
  • Strategies: Reduce Salt and Sugar Intake

Translating Evidence into Practice: Organizational, Behavioral, and Community-Based Interventions and Future Directions in Learning Health Systems
Category: Health Services, Quality Improvement, and Patient-Centered Outcomes

  • Organizational interventions
  • Behavioral Interventions for Lifestyle
  • Community-Based Interventions
  • Stroke Care in Learning Health Systems

Implementation Science in Disadvantaged Settings: Identifying What Works, Where, and How (an AHA/ASA and African Academy of Neurology Joint Symposium)
Category: Community/Risk Factors

  • Culturally tailoring prevention interventions in the community
  • The role of context in implementation research: answering the 'how to' dilemma
  • Responding to challenges in implementation: the role of process evaluation
  • Fidelity: Capturing the Detail to Improve Translation of Research Findings

Game of Strokes

Oral Abstract Sessions

5:30 p.m. – 6:30 p.m.

Moderated Posters

6:30 p.m. – 7:00 p.m.


7:00 a.m. – 8:30 a.m.

Chronic Kidney Disease and Stroke
Category: Community/Risk Factors

  • Epidemiology of CKD and Stroke
  • Neuropathology of CKD
  • CKD and Brain Microvascular Disease
  • Stroke Prevention and Treatment in CKD

One size fits all? Models for thrombectomy systems of care
Category: Acute Endovascular Treatment

  • Challenges in patient access
  • Skip the local center and head straight to the mothership
  • The closest local center is a must: Drip and Ship, or Bust
  • Bring the intervention to the patient: The trip and treat model
  • Lessons learned while studying multiple delivery models

Reperfusion Injury: Fact or Fiction? (Debate)
Category: Vascular Biology in Health and Disease

  • Reperfusion Injury: Fiction
  • Reperfusion Injury: Fact
  • Reperfusion Injury: Fiction (Rebuttal)
  • Reperfusion Injury: Fact (Rebuttal)

The Paola DeRango Memorial Session: Stroke in Women Throughout the Life Course: An International Perspective Stroke in Young Women

  • Peri-menopausal Changes in Stroke Risk
  • Stroke in Postmenopausal Women
  • Marital Status and Stroke

Oral Abstract Sessions

8:30 a.m. – 8:45 a.m.


8:45 a.m. – 10:15 a.m.

Should Endovascular Stroke Therapy for Large Artery Occlusion be Offered to Children? (Debate)
Category: Pediatric Stroke

  • The Neurology Perspective: Arguments in favor of endovascular therapy for the pediatric stroke patient
  • The Neurology Perspective: Arguments against endovascular therapy for the pediatric stroke patient
  • The Endovascular Surgery Perspective: Arguments in favor of endovascular therapy for the pediatric stroke patient
  • The Endovascular Surgery Perspective: Arguments against endovascular therapy for the pediatric stroke patient

Stroke Journal Symposium: Imaging Approaches to Patient Selection for Thrombectomy

  • Overview of Current Practice
  • What imaging was used in the early and late time window thrombectomy trials
  • Advanced imaging is not necessary in most thrombectomy candidates
  • Advanced imaging is helpful in most thrombectomy candidates
  • What future trials are needed to define the role of imaging for thrombectomy patient selection

Stroke Telehealth: Controversies and Solutions (an AHA/ASA and World Stroke Organisation Joint Symposium)
Category: Health Services, Quality Improvement, and Patient-Centered Outcomes

  • Telestroke: State of the Art
  • Global Trends in Telestroke Stroke Care
  • Telestroke Networks in Urban Settings
  • Does Telestroke Consultation Affect Use of Thrombolysis and Thrombectomy?

The Justin Zivin Memorial Session: The Tried and Tested vs the New Kid on the Block: The tPA vs tNK Debate
Category: Acute Nonendovascular Treatment

  • TNK is Ready for Prime Time
  • Stick with the Tried and True rtPA for Now
  • TNK is Ready for Prime Time - Rebuttal
  • Stick with the Tried and True rtPA for Now – Rebuttal

Oral Abstract Sessions

10:15 a.m. – 10:30 a.m.


10:30 a.m. – 12:30 p.m.

Closing Main Event

  • Cross Fire Debate Presentations
  • Thomas Willis Lecture Award Presentation and Lecture
  • Late-Breaking Science Oral Abstracts
  • Closing Remarks, Miguel Perez-Pinzon, PhD, FAHA

The BEST in Stroke Science

Program Description

The International Stroke Conference is the world’s premier meeting dedicated to the science and treatment of cerebrovascular disease. This 2½-day conference features more than 1,500 compelling presentations that emphasize basic, clinical and translational sciences as they evolve toward a better understanding of stroke pathophysiology with the goal of developing more effective therapies. Join us and network with more than 4,500 colleagues in the stroke field from around the world with wide-ranging expertise and experience.

Clinical Sessions focus on community risk factors; emergency care; acute neuroimaging; acute endovascular and acute nonendovascular treatment; diagnosis of stroke etiology; cerebral large artery disease; in-hospital treatment; clinical rehabilitation and recovery; and health services, quality improvement, and patient-centered outcomes. Basic Science Sessions focus on vascular biology in health and disease; basic and preclinical neuroscience of stroke recovery; and experimental mechanisms and models. Further specialized topics include pediatric stroke; intracerebral hemorrhage; nursing; preventive strategies; vascular cognitive impairment; aneurysms; subarachnoid hemorrhage; neurocritical care; vascular malformations; and ongoing clinical trials.

Presentations on these topics attract a wide range of healthcare professionals and investigators including adult and pediatric neurologists; neurosurgeons; neuroradiologists and interventional radiologists; physiatrists; emergency medicine specialists; primary care physicians; hospitalists; nurses and nurse practitioners; rehabilitation specialists; physical, occupational, and speech therapists; pharmacists; and basic researchers spanning the fields of cerebrovascular function and disease.

Education. Inspiration. Illumination. The International Stroke Conference - connecting the world to stroke science.

Learning Objectives

At the conclusion of the International Stroke Conference, participants should be able to:

  • Identify recent advances in basic models of stroke and their translation to clinical research.
  • Evaluate recent advances in the diagnosis, treatment, prevention and rehabilitation of cerebrovascular disease.
  • Analyze new and ongoing advances in clinical research through late-breaking science and ongoing clinical trials sessions.
  • Discuss new research, treatments and interventions with scientists and investigators working in all areas of cerebrovascular disease.
  • Interpret the rapidly changing areas within the stroke spectrum such as emerging options for the diagnosis and treatment of acute stroke, mechanisms of stroke recovery, and the impact of vascular cognitive impairment.
  • Appraise the diverse challenges presented by cerebrovascular disease to specific populations, including ethnic and racial minorities, women, children, and developing communities.