Science News

Hypertension 2019 Scientific Sessions

September 5–8, 2019
New Orleans Marriott | New Orleans, Louisiana

Thursday, Sept. 5

Hypertension 2019 program highlights

Curt Sigmund, PhD, chair of the Council on Hypertension Scientific Sessions Planning Committee and Jan Basile, MD, vice chair of Clinical Programs, preview some of the science they have planned for the program at this year's meeting in New Orleans.

Attendees gathered at the Hypertension 2019 Scientific Sessions in New Orleans.

Attendees gather in New Orleans

By all accounts, this year's Hypertension Scientific Sessions is off to a great start, with cardiovascular professionals from all over the world in attendance. See photos from this year's conference.

Early and Late Post-Kidney Transplant Hypertension and Late Renal Allograft Outcome
Ekamol Tantisattamo | University of California Irvine School of Medicine, Orange, CA

  • RESULTS: One month after a kidney transplant is a good time to check BP levels. Too liberal or tight BP control in normotensive or hypertensive patients at that point may worsen long-term allograft outcomes.
  • Tantisattamo's Abstract (opens in new window)

Zhenyu Xiong | Sun Yat-Sen University, Guangzhou, China

Intensity of Hypertensive Exposure in Young Adulthood and Subclinical Atherosclerosis in Middle Age
Zhenyu Xiong | Sun Yat-Sen University, Guangzhou, China

Noha M. Shawky| Women?s Health Research Center, University of Mississippi Medical Center, Jackson, MS

Female Offspring of Polycystic Ovary Syndrome Rat Model Exhibit Insulin Resistance and Tendency Toward Increased Blood Pressure With Aging
Noha M. Shawky | Women’s Health Research Center, University of Mississippi Medical Center, Jackson, MS

  • RESULTS: Women whose mothers had polycystic ovary syndrome may be at increased risk for hypertension and metabolic dysfunction with aging, although the mechanisms for the hypertension are not clear.
  • Shawky's Abstract (opens in new window)

Kevin Pezeshkian headshot HTN19

Genetic Polymorphisms Associated With Apparent Treatment-Resistant Hypertension in Patients With Chronic Kidney Disease
Kevin Pezeshkian | Michigan State University, East Lasing, MI

  • RESULTS: Distinct genetic polymorphisms — present in chronic kidney disease patients with apparent treatment-resistant hypertension (ATRH) — may be a unique genetic signature for predisposed risk of ATRH. Further study of this marker may reveal potential therapeutic targets.
  • Pezeshkian's Abstract (opens in new window)

Friday, Sept. 6

Learning to Harness Circadian Rhythms for Better Hypertension Management

John Flack, MD interviews Michelle Gumz, PhD about her work on the exploring possible new ways to harness natural circadian rhythms to better manage hypertension.

Recent Advances in Nutrition and the Microbiome

Jennifer Sasser, PhD interviews Katie Meyer, DSc about her recent research exploring the interaction of nutrition and the microbiome and its impact on blood pressure regulation.

Wei Yue headshot HTN19

Role of GRK4, a Risk Factor for Hypertension, in Breast Cancer
Wei Yue | University of Virginia, Charlottesville, VA

Hypoxic Peripheral Chemoreceptor Activation Engages Sympathetic Brainstem and Hypothalamic Nuclei in Human Subjects
Darius Andreas Gerlach | German Aerospace Center, Cologne, Germany

  • RESULTS: High-resolution brainstem functional magnetic resonance imaging during repeated hypoxia traces brainstem circuits engaged by peripheral chemoreceptors. This method may be relevant for CVD.
  • Gerlach's Abstract (opens in new window)

Sharon D.B. de Morais headshot HTN19

Carotid Body Ablation of TRPV1 Reduces Chemoreflex Sensitivity in Rats With Heart Failure
Sharon D.B. de Morais | University of Nebraska Medical Center, Omaha, NE

  • RESULTS: Applying resiniferatoxin (RTX) to the carotid body of rats with heart failure (HF) reduced chemoreflex sensitivity, indicating an important role for TRPV1 signaling in chemoreflex function in HF.
  • Morais's Abstract (opens in new window)

Samuel Ajamu headshot HTN19

Association of Central Arterial Stiffness With Hippocampal Blood Flow, N-Acetyl Aspartate and Anxiety in Hypertensive Dahl Salt Sensitive Rats
Samuel Ajamu | National Institute on Aging, Baltimore, MD

  • RESULTS: Hypertension and CVD may contribute to dementia and Alzheimer’s disease. Arterial stiffness may reduce cerebral blood flow (CBF); higher CBF is associated with lower anxiety.
  • Ajamu's Abstract (opens in new window)

Saturday, Sept. 7

2019 Excellence Award in Hypertension Research

Joey Granger, PhD, immediate past chair of the Council on Hypertension interviews the 2019 Excellence Award for Hypertension Research recipient Rhian Touyz, MBBCh, PhD about her work on the molecular mechanisms and vascular biology of hypertension.

Recent Trials in Diabetic Nephropathy

Keith C. Ferdinand, MD interviews Donald E. Kohan, MD, PhD about 2 recent trials exploring possible treatments for diabetic nephropathy: SONAR and CREDENCE.

George Bakris – 2019 Irvine Page Alva Bradley Lifetime Achievement Award Winner

Karen Griffin, MD, chair of the Council on Hypertension, interviews this year's Irvine Page & Alva Bradley Lifetime Achievement Award winner, George Bakris, MD, MA.

HTN19 - Trainee Advocacy Mixer

Hypertension 2019 Trainee Advocacy Mixer

The year's Trainee Advocacy Mixer was a big success! Attendees enjoyed spectacular views, great music, and the chance to make professional connections. See more photos from the mixer and the rest of the conference.

Interplay Between Nox5 and Endoplasmic Reticulum Stress Regulates Vascular Signalling in Human Hypertension
Livia L Camargo | University of Glasgow, Glasgow, United Kingdom

  • RESULTS: Nox5 upregulation influences vascular signaling and cytoskeleton reorganization in vascular smooth muscle cells - processes that lead to vascular dysfunction in hypertension.
  • Carmago's Abstract (opens in new window)

Leptin-Thyroliberin Pathway in Left Ventricle Hypertrophy
Maia Aisicovich | Medical Research Institute IDIM, Natl Council of Scientific and Tech Research (CONICET); Buenos Aires Univ (UBA), Buenos Aires, Argentina

  • RESULTS: A study revealed that the Leptin-Thyroliberin pathway is central to Leptin-induced left ventricular hypertrophy (LVH) and described direct thyrotropin-releasing hormone (TRH)-Leptin induction in heart cells.
  • Aisicovich's Abstract (opens in new window)

Amplification of Systolic Blood Pressure and Pulse Pressure is Higher in Resistant Hypertensive Patients Irrespective of Blood Pressure Control
Badhma Valaiyapathi | University of Alabama at Birmingham, Birmingham, AL

Blood Pressure Variation and Renal Functional Changes in Chronic Renal Insufficiency Patients With or Without Diabetes in a Large Cohort Study
Ling Wang | Michigan State University, East Lansing, MI

  • RESULTS: Renal function is worse in chronic kidney disease (CKD) patients with diabetes mellitus (DM) than non-DM CKD patients, but lowering blood pressure may improve renal function. Benefits are biggest on albuminuria in CKD patients with DM.
  • Wang's Abstract (opens in new window)

Sunday, Sept. 8

Hypertension 2019 Early Career Oral Award Recipients

Francine Marques, PhD interviews Giacomo Rossitto, MD and Karen Clark, the basic and clinical recipients of the Hypertension 2019 Early Career Oral Award.

Hypertension 2019 Wrap-Up

Curt Sigmund, PhD, vice chair of the Council on Hypertension and Jan Basile, vice chair of clinical programs recap some of the highlights of Hypertension 2019, including several clinical debates and basic science topics.

Mitochondrial Fission in Vascular Cells Mediates Hypertensive Vascular Remodeling and Inflammation
Hannah Cooper | Temple University, Philadelphia, PA

  • RESULTS: Inhibition of mitochondrial fission prevents angiotensin II-induced CV remodeling and inflammation by attenuating vascular smooth muscle cells and endothelial cell signaling events.
  • Cooper's Abstract (opens in new window)

Sex-Differences in Fetal Programming of Cardiomyopathy Induced by Hypertensive Disorders of Pregnancy in Mice
Mariane Bertagnolli | CIUSSS Nord-de-l'Île-de-Montréal, Montréal, QC, Canada

  • RESULTS: A study validated a new ultrasound imaging protocol to describe sex-differences in the fetal programming of cardiomyopathy in a genetic mice model of maternal hypertension and superposed pre-eclampsia. It showed that fetal cardiac remodeling changes persisted into adulthood in offspring of hypertensive mothers.
  • Bertagnolli's Abstract (opens in new window)