Science News from Vascular Discovery 2019

Vascular Discovery: From Genes to Medicine
Scientific Sessions 2019

Formerly ATVB|PVD Scientific Sessions

May 14–16, 2019
Marriott Copley Square Hotel | Boston, Massachusetts

Sponsored by: Arteriosclerosis, Thrombosis and Vascular Biology Council
Peripheral Vascular Disease Council and Genomics & Precision Medicine Council

This is where you'll find exclusive science content from Vascular Discovery 2019. For coverage from previous years, check our archive page.

Tuesday's selected science

Sex Differences in Vascular Disease

Lars Maegdefessel, MD, PhD, vice chair for Vascular Discovery 2019, interviews Lisa Cassis, PhD about her work on sex difference in vascular diseases, which she presented during the meeting in Boston.
Dawn Fernandez | Mount Sinai School of Medicine, New York, NY

Single-cell Profiling of Atherosclerotic Tissue Identifies T Cell Subsets Associated with Cerebrovascular Events
Dawn Fernandez | Mount Sinai School of Medicine, New York, NY

Diego Lucero | NHLBI-NIH, Bethesda, MD

Transgelin: A New Gene Involved in LDL Endocytosis in Liver Cells Identified by a Whole-genome Crispr-cas9 Screen
Diego Lucero | NHLBI-NIH, Bethesda, MD

Bronwyn Kingwell | Baker Heart and Diabetes Institute, Melbourne, Australia

ApoA-I nanoparticles (CSL-111) Directly Modulates Inflammatory Cells After Myocardial Infarction in Mice
Bronwyn Kingwell | Baker Heart and Diabetes Institute, Melbourne, Australia

  • RESULTS: Identification of the anti-inflammatory mechanism for apolipoprotein A-I nanoparticles (n-apoAI) helps to explain the reduction in infarct size and the improvement in heart function seen when n-apoAI is given immediately after an MI.
  • Kingwell's Abstract (opens in new window)
Constance J Mietus | UNMC, Omaha, NE

Microvascular Pathology Influences Walking Performance in Patients with Peripheral Artery Disease
Constance J Mietus | UNMC, Omaha, NE

Sean P. Doherty | Vanderbilt University Medical Center, Nashville, TN

DNA Base Editing in Hutchinson-Gilford Progeria Syndrome
Sean P. Doherty, Vanderbilt University Medical Center, Nashville, TN

2019 Early Career Investigator Award Recipients - read more

Katey Rayner | Ottowa, ON, Canada

Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer microRNA to Inhibit Cell Migration
Jan. 1, 2018 | ATVB

Keith B. Neeves | Golden, CO

Platelets Drive Thrombus Propagation in a Hematocrit and Glycoprotein VI Dependent Manner in an in vitro Venous Thrombosis Model
May 1, 2018 | ATVB

Katherine A Gallagher | Ann Arbor, MI

Ly6CHi Blood Monocyte/ Macrophage Drive Chronic Inflammation and Impair Would Healing in Diabetes
April 1, 2018 | ATVB

Wednesday's selected science


Intersections between the vascular system and cancer

Kathleen Martin, PhD interviews Rosandra Kaplan, MD about her research on perivascular cell plasticity in metastatic progression, which she presented Wednesday morning in the plenary session "Intersections Between the Vascular System and Cancer."


Lessons from the AHA Strategically Focused Research Network on Vascular Disease

Aruna Pradhan, MD, MPH, chair of the AHA Council on Peripheral Vascular Disease, interview Francis Miller, MD, Director of the Oversight Committee for the AHA SFRN on Vascular Disease about the lessons being learned from this new approach to research.

Microbial Colonization Restores Neointimal Hyperplasia Development After Arterial Injury in Germ-Free Mice
Edmund B Chen | Northwestern University, Feinberg School of Medicine, Chicago, IL

  • RESULTS: Fecal transplantation into germ free mice suggests that gut microbiota may play a role in hyperplastic neointimal development and arterial remodeling.
  • Chen's Abstract (opens in new window)
Katarina Wadén | Karolinska Institute, Stockholm, Sweden

Correlation of Clinical Risk Scores for Stroke with Carotid Plaque Gene Expression Profiles in Atherosclerotic Patients
Katarina Wadén | Karolinska Institute, Stockholm, Sweden

  • RESULTS: Plaque vulnerability, a molecular process, was associated with high clinical risk scores for stroke using the ABCD2 clinical risk score and Carotid Artery Risk (CAR) scores.  The most upregulated gene in high-risk groups, ABCB5, was identified as a key novel gene in unstable plaque.
  • Wadén's Abstract (opens in new window)
Alyssa M. Flores | Stanford University, Stanford, CA

Efferocytosis-stimulating Nanoparticles for Precision Atherosclerosis Therapy
Alyssa M. Flores | Stanford University, Stanford, CA

  • RESULTS: Precision-targeted nanotherapeutics normalized the atherosclerotic plaque by targeting the "don't eat me" molecule, CD47. CD47 that makes cells resistant to the removal of dead cells from the vessel walls (effercytosis).
  • Flores' Abstract (opens in new window)
Brian Ghoshhajra | Massachusetts General Hospital, Harvard Medical School, Boston, MA

Coronary Atheroma Regression from Serial Infusions of Autologous Selectively Delipidated Preβ-HDL-enriched Plasma on Coronary Atheroma in Patients With Homozygous Familial Hypercholesterolemia in the HALO-FH Trial
Brian Ghoshhajra | Massachusetts General Hospital, Harvard Medical School, Boston, MA

Young Investigator Awards

ATVB Kenneth M. Brinkhous Young Investigator Prize in Thrombosis Finalists

The Brinkhous Prize recognizes outstanding endeavors by new investigators in fundamental and applied research in thrombosis.


Ashley Brown | North Carolina State University, Raleigh, NC


Lacramioara Ivanciu | Children's Hospital of Philadelphia / University of Pennsylvania, Philadelphia, PA



Ze Zheng | Columbia University Medical Center, New York City, NY

ATVB Irvine H. Page Young Investigator Research Award Finalists

The Page Award encourages investigators to continue careers in arteriosclerosis and vascular biology and recognizes talented investigators at an early or beginning point in their careers.


Alison B Kohan | University of Connecticut, Storrs, CT


Ekaterina Koltsova | Fox Chase Cancer Center, Philadelphia, PA


Bhama Ramkhelawon | NYU Medical Center, New York, NY


Thursday's selected science


2019 Mentor of Women Award Winner Nancy Webb

Mary Sorci-Thomas, PhD interviews the Vascular Discovery 2019 Mentor of Women Award Winner Nancy Webb, PhD.


The Interplay of Innate and Adaptive Immune Responses in Atherosclerosis

Alan Daughtery, PhD, DSc interviews Ziad Mallat, MD, PhD about his research into the interplay of innate and adaptive immune responses in atherosclerosis.

Winner A. Phillip Owens III is flanked by Aruna Pradhan and Naomi Hamburg.

Robert W. Hobson II MD Early Career Investigator Award

Winner A. Phillip Owens III, PhD, of the University of Cincinnati is flanked by AHA volunteers Aruna Pradhan, MD, MPH and Naomi M. Hamburg, MD, MS.

Winner Ashish K. Sharma is flanked by Aruna Pradhan and Naomi Hamburg.

Alan T. Hirsch MD Mid-Career Award in Vascular Medicine

Pictured left to right: Aruna Pradhan, MD, MPH, award winner Ashish K. Sharma, MBBS, PhD of the University of Florida, and Naomi M. Hamburg, MD, MS.

Kathryn Moore | New York University Langone Health, New York, NY

Acute Myocardial Infarction Accelerates Breast Cancer Progression Through Innate Immunity
Kathryn Moore | New York University Langone Health, New York, NY

  • RESULTS: In animal models of breast cancer, an acute myocardial infarction (AMI) increased tumor growth and metastatic burden with changes in the tumor microenvironment and tumor immune cell.
  • Moore's Abstract (opens in new window)

Coronary Artery Disease-associated Genetic Variants Increased Lipa Expression and Overexpression of Lipa Induced Atherogenic Phenotypes in Macrophages
Fang Li | Department of Medicine, Columbia University Irving Medical Center, New York, NY

  • RESULTS: Genetic variants associated with coronary artery disease increased LIPA expression which caused more atherogenic phenotypes in macrophages.
  • Fang's Abstract (opens in new window)