- The rates of both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are increasing in youth.
- Two- to 10-fold increases in rates of coronary heart disease and death resulting from coronary heart disease in T1DM were reported in multiple studies involving adults.
- One approach to cardiovascular disease risk reduction in diabetes mellitus uses the A, B, C approach. In addition to glucose control (HbA1c, or A), blood pressure (BP or B), and cholesterol (C) management are emphasized.
- Modifiable CVD risk factors for people with diabetes mellitus include obesity, IR, inflammation, oxidative stress, kidney disease, and lifestyle factors such as smoking, diet, exercise, psychosocial stress, depression, and sleep.
- Non-modifiable CVD risk factors include genetics, family history, diabetes mellitus duration, and racial/ethnic disparities.
- More clinical trial information is needed to better understand pharmacological treatment and prevention of risk factors.
Read the full article in Circulation