Advances in MicroRNA Research
MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities
By targeting tropomyosin1, MicroRNA-21 (miR-21) regulates arterial smooth muscle cell function by targeting tropomyosin 1, playing an important role in obliterans (ASO). Although more research is warranted, these findings might provide a new therapeutic target for human ASO.
Induction of MicroRNA-1 by Myocardin in Smooth Muscle Cells Inhibits Cell Proliferation
Myocardin is a cardiac- and smooth muscle–specific transcription co-factor that when overexpressed inhibits the proliferation of smooth muscle cells and has been found to induce the expression of microRNA-1 (miR-1) in cardiomyocytes. In order to mediate its inhibition of smooth muscle cell proliferation, myocardin induces miR-1 expression.
Inhibition of MicroRNA-29 Enhances Elastin Levels in Cells Haploinsufficient for Elastin and in Bioengineered Vessels—Brief Report
In cells and tissues lacking elastin, miR-29 inhibition increases elastin levels. Antagonizing miR-29 was shown to promote increased ELN levels during conditions of ELN deficiencies.
Integrative Physiology/Experimental Medicine: Transforming Growth Factor-β–Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21
Transforming growth factor-β (TGF-β) is involved in cardiac fibrosis by stimulating endothelial-to-mesenchymal transition (EndMT). miRNA-21 has a role in the regulation of cardiac TGF-β-mediated EndMT via the phosphatase and tensin homolog/Akt pathway through the blockade of EndMT under stress conditions.
Ets-1 and Ets-2 Regulate the Expression of MicroRNA-126 in Endothelial Cells
MicroRNA-126 (miR-126) is highly expressed in endothelial cells, regulating angiogenesis and vascular inflammation. Transcription factors Ets-1 and Ets-2 regulate miR-126 expression and may mediate some of their vascular effects.