Advances in MicroRNA Research

Updated:Apr 18,2013
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Advances in MicroRNA Research

MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities
Wang M, Li W, Chang G-Q, Ye C-S, Ou J-S, Li X-X, Liu Y, Cheang T-Y, Huang X-L, Wang S-M. MicroRNA-21 Regulates Vascular Smooth Muscle Cell Function via Targeting Tropomyosin 1 in Arteriosclerosis Obliterans of Lower Extremities. Arterioscler Thromb Vasc Biol. 2011;31:2044-2053, doi:10.1161/ATVBAHA.111.229559
Abstract

   

By targeting tropomyosin1, MicroRNA-21 (miR-21) regulates arterial smooth muscle cell function by targeting tropomyosin 1, playing an important role in obliterans (ASO). Although more research is warranted, these findings might provide a new therapeutic target for human ASO.

 


 

Induction of MicroRNA-1 by Myocardin in Smooth Muscle Cells Inhibits Cell Proliferation
Chen J, Hao Y, Jiang Y, Radhakrishnan SK, Huang Z-P, Li J, Shi Z, Kilsdonk EPC, Gui Y, Wang D-Z, Zheng X-L. Induction of MicroRNA-1 by Myocardin in Smooth Muscle Cells Inhibits Cell Proliferation. Arterioscler Thromb Vasc Biol. 2011;31:368-375. doi:10.1161/ATVBAHA.110.218149.
Abstract

 

Myocardin is a cardiac- and smooth muscle–specific transcription co-factor that when overexpressed inhibits the proliferation of smooth muscle cells and has been found to induce the expression of microRNA-1 (miR-1) in cardiomyocytes. In order to mediate its inhibition of smooth muscle cell proliferation, myocardin induces miR-1 expression.

 


 

Inhibition of MicroRNA-29 Enhances Elastin Levels in Cells Haploinsufficient for Elastin and in Bioengineered Vessels—Brief Report
Zhang P, Huang A, Ferruzzi J, Mecham RP, Starcher BC, Tellides G, Humphrey JD, Giordano FJ, Niklason LE, Sessa WC. Inhibition of MicroRNA-29 Enhances Elastin Levels in Cells Haploinsufficient for Elastin and in Bioengineered Vessels—Brief Report. Arterioscler Thromb Vasc Biol. 2012;32:756-759 published online before print November 17, 2011, doi:10.1161/ATVBAHA.111.238113
Abstract

 

In cells and tissues lacking elastin, miR-29 inhibition increases elastin levels. Antagonizing miR-29 was shown to promote increased ELN levels during conditions of ELN deficiencies.

 


 

Integrative Physiology/Experimental Medicine: Transforming Growth Factor-β–Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21
Kumarswamy R, Volkmann I, Jazbutyte V, Dangwa S, Park D-H, Thum T. Integrative Physiology/Experimental Medicine: Transforming Growth Factor-β–Induced Endothelial-to-Mesenchymal Transition Is Partly Mediated by MicroRNA-21. Arterioscler Thromb Vasc Biol. 2012;32:361-369, published online before print November 17, 2011, doi:10.1161/ATVBAHA.111.234286.
Abstract

 

Transforming growth factor-β (TGF-β) is involved in cardiac fibrosis by stimulating endothelial-to-mesenchymal transition (EndMT). miRNA-21 has a role in the regulation of cardiac TGF-β-mediated EndMT via the phosphatase and tensin homolog/Akt pathway through the blockade of EndMT under stress conditions.

 


 

Ets-1 and Ets-2 Regulate the Expression of MicroRNA-126 in Endothelial Cells
Harris TA, Yamakuchi M, Kondo M, Oettgen P, Lowenstein CJ. Ets-1 and Ets-2 Regulate the Expression of MicroRNA-126 in Endothelial Cells. Arterioscler Thromb Vasc Biol. 2010;30:1990-1997 published online before print July 29, 2010, doi:10.1161/ATVBAHA.110.211706.
Abstract

 

MicroRNA-126 (miR-126) is highly expressed in endothelial cells, regulating angiogenesis and vascular inflammation. Transcription factors Ets-1 and Ets-2 regulate miR-126 expression and may mediate some of their vascular effects.