American Stroke Association-Bugher Foundation Centers of Excellence In
Stroke Collaborative Research for Regeneration, Resilience and Secondary Prevention
The Henrietta B. and Frederick H. Bugher Foundation has joined with the American Stroke Association (ASA, a division of the American Heart Association) to support a network of three Centers of Excellence in Stroke Collaborative Research for a period of four years.
The intent of this initiative is to support a collaboration of basic, clinical and population researchers from different specialties whose collective efforts will lead to new approaches, not only to improve the prevention of stroke, but to also expand upon the previous Bugher Stroke initiatives by inviting research on recovery after a stroke; including the areas of repair, regeneration, neuro-plasticity and rehabilitation.
A focus has again been placed on fellowship training and cross-center collaboration for this most recent initiative. Awardees were chosen based on their capability to not only train fellows in stroke research, but also their commitment to collaborate with scientists outside their institution.
These awards will begin April 1, 2014 and will run through March 31, 2018. The Centers are located at the following institutions:
University of California, Los Angeles
These studies will test new methods to limit cerebrovascular damage and disease progression, promote activity-based rehabilitative recovery after stroke, and identify the molecules that mediate brain repair that is produced by rehabilitative activity. These studies will be conducted in mouse and human applications, and provide information on molecules that might serve as new drug targets for brain repair and on readily applied human interventions to promote brain resilience and improve recovery.
University of Colorado, Denver
The goal is to understand how children recover from stroke. Once we understand more about the mechanisms of injury, recovery and repair, we can then try to restore function to these injured brains and try to determine how to restore some of the remarkable brain plasticity that is lost with age. These experiments will better help us to understand how to relieve the harmful consequences of stroke, thereby allowing people to more fully recover from the devastating effects of heart disease on the brain.
University of Miami
We will address specific evidence gaps in our knowledge of approaches to improve cognitive outcomes after stroke. In our clinical trial, we hope to show the cognitive benefits of a Combined Aerobic and Resistance Exercise Training (CARET) program and a Cognitive Training Intervention (CTI) program after ischemic stroke. In our animal studies, we hope to demonstrate that the combination of enriched environment (EE), physical exercise (PE), and pharmacological intervention can have a positive impact on the cognitive and functional recovery outcomes after MCAo in middle age and old rats. We believe that these combined multi-modal therapeutic approaches will provide data needed to develop specific strategies to ameliorate cognitive deficits after ischemic stroke and can provide the next steps for clinical trials added to those proposed in Project 1 of this application.
Awards are limited to non-profit institutions in Canada, Mexico and the United States, such as universities and colleges, public and voluntary hospitals, laboratories, research institutes, and other non-profit institutions that can demonstrate the ability to conduct projects and organize a center.
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