CVGPS Letter of Application (LOA) Requirements

Updated:May 19,2014

CVGPS Pathway Letter of Application Due June 3

The following must be met for each of the CVGPS Letter of Application (LOA) Required Documents:

FORMAT/TYPE REQUIREMENTS


The documents below must be created as a Word-processed document, converted to a Portable Document Format (PDF) file, and uploaded to Grants@Heart. Only PDF files will be accepted. When creating the documents, you must comply exactly with the association's format/type requirements and page limit.  Failure to comply will result in the administrative withdrawal (disqualification) of the application. 

  • Only Portable Document Format (PDF) files will be accepted.
  • Document must be single-spaced.
  • No more than 15 characters per inch (cpi) or an average of no more than 15 cpi (cpi includes symbols, punctuation and spaces).
  • No less than ¾" margins allowed.
  • 60 lines per page are the maximum allowed (The average number of lines per page using the font and point size below will be approximately 50-55 lines)
  • Arial Font style, 12 point font size for Windows users; Helvetica Font style, 12 point font size for Macintosh users
  • Figures, charts, tables, graphics and legends may be smaller in size but must be clear and legible
Users of other word processing programs must adjust settings appropriately and should measure text after saving and printing as a PDF. Type requirements should be checked using a standard measuring device (such as a ruler), rather than relying on the font selected for a particular word processing/printer combination. Type size specifications must be observed in the text of your research plan or the application will not be reviewed and will be withdrawn. Adherence to font and margin requirements is necessary. No applicant should have an advantage over other applicants by providing more content in his/her application by using smaller, denser type. The AHA has the responsibility to make the final determination of conformance to format requirements and the authority to withdraw applications. This decision is final and not subject to appeal.

Internet Web site addresses (URLs) may not be used to provide information necessary to the review because reviewers are under no obligation to view the internet sites. Moreover, the reviewers are cautioned not to directly access an Internet site as it could compromise their anonymity.

Create the documents specifically following each outline given below. All documents should include the following items addressed. Do not exceed the provided page limits. Each numbered item indicates a separate document that must be uploaded in Grants@Heart.

  1. Project Description (1 page limit)*
    What is the title and specific scientific problem that will be addressed and why is this important? What are the innovative or high-risk, high-reward approaches that, if successful, might lead to paradigm-shifting results? Does the project address a critical barrier to progress in the field? Are novel approaches, methodologies, tools or technologies being used for this project?

    Although information about personnel and environment are contained in other areas of the AHA application, if you desire you may include brief information about unique features to this project (such as personnel, features of the scientific environment, subject populations, or collaborative arrangements). (This is not required.)

    *This is a combination of I and II within the RFA. 
     
  2. Specific Aims (limit to 1 page single spaced)
    Provide a clear, concise summary of the aims of the work proposed and its relationship to your long-term goals.  State the hypothesis to be tested.
     
  3. Relevance and Importance to the CVGPS Program (limit to 1 page single spaced)
    Summarize important results outlined by others in the same field, critically evaluating existing knowledge.  Identify gaps that this project is intended to fill.

    State concisely the importance and relevance of the research to cardiovascular function or disease, stroke, or to related fundamental problems. Also, it is incumbent upon the applicant to make a clear link between the project and the mission of the AHA.  The significance section will be assessed in terms of potential impact on the AHA mission; this will be factored into the overall priority score as noted in the peer review criteria.
     
  4. Description of Research Methods (limit to 1 page single spaced)
    Provide a brief description of research methods associated with your proposed project (e.g. Rt-pcr, gene assays, etc.).
     
  5. Data Cohort Identification
    Download the Data Cohort Identification form. When completed, convert the Word file to a PDF and upload within Grants@Heart.
     
  6. Proof of Informed Consent
    IF proposing a new cohort or new individual testing of a current cohort, describe your Informed Consent procedures. Note: only applicants receiving an invitation for a Full Application later in the process will need to provide evidence of IRB consent.
     
  7. Data and Bio Sample Quality Management Protocol Summary (1 page limit)
    Briefly describe your quality management protocol for data and bio samples. In Grants@Heart, may upload a full quality management protocol. If you do not wish to include a full quality management protocol, simply create a PDF that states "None" and upload it. 
     
  8. Computer Security Protocols (include levels)
    Due to the sensitivity of the FHS and JHS cohort data, briefly describe computer security protocol and include levels of security that will be taken during your research to protect the data.
     
  9. IRB Approval
    Describe if you have IRB approval for the proposed project at your institution. If you do not currently have IRB approval, describe where you are in the IRB approval process.
     
  10. Description of Statistical Methods to Include Power Calculations (1 page limit)
    Describe different statistical tests used to analyze final data including power calculations. Clearly describe overall design of the study, with careful consideration to statistical aspects of the approach, the adequacy of controls, and number of observations, as well as how results will be analyzed.
     
  11. Budget Justification
    Download and complete the budget justification form. When completed, convert the Word file to a PDF and upload within Grants@Heart.
     
  12. Biosketch for Principal Investigator and Other Team Members (5 page limit per person)
    A biographical sketch is needed for each person working on the proposed project (e.g. principal investigator, joint (co-) principal investigator, consultant, statistician, lab personnel, etc.). If you have a copy of a current biographical sketch that you submitted with an NIH application you may use it. If you don't have an NIH biographical sketch, create a document using the biosketch directions
     
  13. Training Plan for Fellow
    An Individual Development Plan (IDP), is preferred. For more information, visit the IDP instructions.
     
  14. Literature Cited 
    List all literature citations for your proposed project. There is no page limit for literature references cited.

    Citation references should be limited to relevant and current literature; be concise and select only those references cited in the proposed project. Standard abbreviations are acceptable with two exceptions: full titles and full paging must be provided.

    Each reference must list the: 

    • authors in the same order as they appear on the paper (list all or up to 15)
    • title
    • name of the book or journal
    • volume number
    • page numbers
    • year of publication

Applications to the CVGPS LOA will be assigned to a group of multidisciplinary reviewers. You may be writing for a reviewer in a related field and an expert directly in your area. Aim the application at both the expert in the field and at the generalist. The level of detail should be appropriate for reviewers who have a broad knowledge of the scientific area.

Notice: the Grants@Heart electronic system will reject a document that exceeds the page limit.

CVGPS Frequently Asked Questions