CVGPS Frequently Asked Questions

Updated:Aug 28,2014

Frequently Asked Questions
American Heart Association Cardiovascular Genome Phenome Study (CVGPS)

  1. How many Pathway Grants will be awarded?
    The number of Pathway Grants to be awarded by calendar period is as follows:
    2014-2015:  8
    2015-2016: 6
    2016-2017: 8
    2017-2018: 6
    2018-2019: 6
     
  2. How many Challenge Grants will be awarded?
    One Challenge Grant will be awarded between July 1st and June 30th for each of the following years:  2014-2015, 2016-2017, and 2018-2019.
     
  3. Can an individual apply for both types of awards?
    Yes, an individual can apply for both types of awards, however there can be no scientific overlap between the different award submissions.
     
  4. Can there be more than one principal investigator named in an application?
    Yes, multiple principal investigators are permissible per award. 
     
  5. Only Framingham Heart Study and Jackson Heart Study data are specifically named in the Request for Applications.  Can data sets from other population studies be used?
    Yes, new data from new clinical/population samples exclusive or inclusive of FHS/JHS datasets or new enhanced data from other established cohorts may be used.
     
  6. Are both metabolomics and proteomic studies appropriate for submission?
    Yes, both metabolomics and proteomic studies are within the scope of CVGPS grant mechanisms.
     
  7. Can you provide an example of how external data might interface with data from FHS/JHS?
    The integration of data sets from various sources may be particularly useful in the study of gene/phenotype and environment interactions or in enhancing risk factor prediction. For example, one might conduct a comparison of data on outcomes (and related gene/phenotype interactions) using data from the Centers for Medicare and Medicaid Services (CMS) in efforts to enhance characterizations of hospitalizations for selected outcomes of interest and characterizations of potential exposures to prescription medications not ascertained by the parent studies.

    In all instances where external data will be used, investigators will still be required to adhere to the practices established by the parent studies of those databases to protect the quality and confidentiality of the data and samples. 
     
  8. When new cohorts are involved, will the data or resources from those cohorts be added to the CVGPS resource?
    The addition of data and/or resources from new cohorts will be evaluated on a case-by-case basis by the CVGPS Scientific Oversight Committee and adhering to the data sharing policies and procedures of the new cohort studies.
     
  9. If I have questions, should I call the NIH, NHLBI, or investigators from Framingham or Jackson Heart Studies?
    Questions or comments should be directed to the American Heart Association via email to apply@heart.org.  You will receive an acknowledgement response typically within 72 hours.  Final answers to some inquiries may be more complex and require longer timeframes to determine, but in all instances you will be advised of the timeframe by an AHA staff member.
     
  10. Can JHS/FHS investigators at Jackson or Boston be named as a Co-Investigator and receive FTE acknowledgement?
    Yes. While no minimum percent effort is specified, the percentage effort of the PI will be part of the application and must demonstrate that adequate time will be devoted to ensure successful completion of the proposed project.
     
  11. Can intramural NHLBI investigators be named as a co- investigator?
    Yes. (See number 10 above). If the co-investigator has adequate time to devote to ensure successful completion of the proposed project, an intramural NHLBI investigator could be named as a co-investigator.
     
  12. When will the grant agreement be available for review assuming that such a document will be used, and if such a document will be used will there be a version specific for a Federal agency (e.g., National Institutes of Health)?  Or will Awardee just be expected to follow the regulations and policies of the grant programs of the AHA?
    The award agreement will be made available to the recipient and their institution after notification of receipt of award.  The awardee will be expect to follow the regulations and policies of the grant programs of the AHA.
     
  13. In a situation wherein the application includes multidisciplinary teams (collaborative arrangement) from more than one entity, how are the grant funds distributed to the separate entities?  Or is the distribution of funds left up to the Awardee to arrange?
    One institution will be named in the award agreement and distribution of funds is the responsibility of that institution. The expected funding distribution to collaborative institutions will be part of the application.  Deviation from that funding distribution will require an exception from the AHA.
     
  14. For either the Pathway or Grand Challenge, can a PI submit more than one LOA?  If not, can a person be a PI on one LOA, and a co-investigator on another?
    Only one application may be submitted per investigator for each grant mechanism.   Multiple applications may be submitted from one institution.  Yes, an investigator could be the PI on one LOA and a co-investigator on another.
     
  15. Can international PIs apply for grants from the CVGPS?
    Yes.  It is acceptable for a US Institution based Contact PI to have a financial relationship with a PI in a foreign country.  The AHA pays an award eligible US Institution and it is up to the Contact PI and the US Institution to distribute the dollars to the foreign institution and PI.

    Currently direct funding of foreign institutions would be prohibited: Awards for research to be performed outside the United States are limited to Principal Investigators who are United States citizens. Awardees, who are US citizens, may request AHA approval to temporarily conduct work in foreign countries (e.g., outside US, Canada and Mexico) with AHA Award funds to be administered through a US institution.
     
  16. Do all grant applications have to have a training component?
    Yes. One of AHA’s research guiding principles is to support training and mentoring of early career scientists. The CVGPS grants provide unique opportunities to achieve this goal and applications need to include this component.
     
  17. Should applicants submit an ancillary study proposal to either JHS or FHS in advance of submitting the AHA application to help expedite approval?
    No.  CVGPS grant mechanisms have a procedure in place that provides for initial scientific review by AHA prior to initiating the review processes at either JHS or FHS. By restricting submissions of AHA ancillary study requests to this process, we can avoid possible redundancy and confusion and thereby streamline the AHA/JHS/FHS review procedure.
     
  18. Are data and/or specimens available to potential CVGPS applicants in order to conduct pilot studies in preparation for submission of an AHA Pathway Grant or Grand Challenge award?
    No.  At this time, pilot data and/or specimens are not available to CVGPS applicants.
Download a copy of the CVGPS FAQs (PDF).