AHA Cardiovascular Genome Phenome Study (CVGPS)

NEW! AHA CVGPS Awards Funded by AstraZeneca

AstraZeneca (AZ) has provided support to AHA to fund multiple researchers over 12 months to answer three strategic impact questions that are currently being developed.  Check back in early May for more information regarding this funding opportunity, including the formal Request for Applications.

American Heart Association Cardiovascular Genome Phenome Study (CVGPS)

The Cardiovascular Genome Phenome Study (CVGPS) is a collaborative effort, spearheaded by the American Heart Association (AHA), to accelerate the future of cardiovascular medicine. CVGPS combines the power of long-term population studies with the precision of molecular analysis to unravel key distinctions between and within subgroups of patients. The discoveries it generates will point the way toward better-targeted, safer, and more effective treatments, based on a deeper understanding of patients’ characteristics, including e.g. risk profiles and therapeutic needs.

The CVGPS is a collaboration among AHA, Boston University (BU) and the University of Mississippi Medical Center (UMMC), the academic coordinating center homes, respectively, of the Framingham Heart Study (FHS) and the Jackson Heart Study (JHS). The Jackson Heart Study also involves Jackson State University (JSU) and Tougaloo College (TC) as partner institutions.

Through the rich diversity of constituent participant/patient populations, CVGPS research will bring inter-individual and patient-to-patient differences into ever sharper focus for common diseases such as atherosclerosis and hypertension.

CVGPS Award Terms and Conditions

Learn more about CVGPS

Introduction to CVGPS
Joseph Loscalzo, M.D., Ph.D., FAHA
Chair, CVGPS Science Oversight Committee
Boston University / Framingham Heart Study's (FHS) Role
Vasan Ramachandran, M.D.
The University of Mississippi / Jackson Heart Study's (JHS) Role
Adolfo Correa, M.D., Ph.D.
NHLBI and Its Role
Michael Lauer, M.D., FAHA
Announcement of CVGPS Pathway Grant Recipients
Steven R. Houser, Ph.D., FAHA
Chair, AHA Research Committee

CVGPS Publications

Harnessing the immune system to prevent heart disease
American Heart Association Blog | May 21, 2015

Cracking the genetic code on heart problems in African-Americans

American Heart Association Blog | May 5, 2015

Smothering the fires within

American Heart Association Blog | April 17, 2015

CVGPS researcher aims to help prevent and treat stroke with plumbing fix

American Heart Association Blog | April 3, 2015

AHA supporters donate millions for research
American Heart Association Blog | March 31, 2015

CVGPS research aims to improve common blood pressure medication

American Heart Association Blog | March 20, 2015

Obama details 'precision medicine' research initiative

American Heart Association Blog | Jan. 30, 2015

American Heart Association Cardiovascular Genome-Phenome Study: Foundational Basis and Program

Circulation | Nov. 19, 2014

View the Cardiovascular Genome Phenome Study Awardees

Funding Opportunities

Coming soon! AHA CVGPS Awards Funded by AstraZeneca

  • One-year awards to address specific high impact questions
  • Approximately $160K per award
  • RFA to be released in early May 2015

CVGPS Pathway Grants

  • Funded at $250,000/year for 2 years for a total of $500,000

CVGPS Grand Challenge Awards

  • Funded at $500,000 for 4 years for a total of $2 million
  • Next Grand Challenge Awards will be offered in 2016

CVGPS Frequently Asked Questions