Duke University
Larry Goldstein, M.D. - Center Director    
Science Project Title: Bugher Foundation Center for Stroke Prevention Research
Award start date: 7/1/2007  Award End Date: 6/30/2011  Total Award Amount: $2,660,000

Larry Goldstein, M.D. - Project 1 PI
Institution: Duke University
Project Title: Small Vessel-Type Intracranial Disease Risk: Whole Genome Association Studies

Cheryl Bushnell, M.D. - Project 2 PI
Institution: Wake Forest University
Project Title: Biomarkers and Nitric Oxide Synthase Genotypes in African Americans with Intracranial Small Vessel-Type Disease

Massachusetts General Hospital
Karen Furie, M.P.H., M.D. - Center Director
Project Title: Harvard ASA-Bugher Center for Stroke Prevention & Genetic Research
Award start date: 7/1/2007  Award End Date:  6/30/2011  Total Award Amount: $2,101,280

Jonathan Rosand, M.D., M.Sc. - Project 1 PI
Institution: Massachusetts General Hospital
Project Title: Genetic Determinants and Outcomes of White Matter Hyperintensity

Dong Kim, M.D. - Project 2 PI
Institution: University of Texas, Houston
Project Title: Identification of Coding Variants Associated with Cerebral Aneurysm Pathogenesis

University of California, Davis
Frank Sharp, M.D. - Center Director
Project Title: ASA-Bugher Foundation Center for Stroke Prevention Research: Genomics and Genetics of TIA's and Stroke in Humans
Award start date: 7/1/2007  Award End Date: 6/30/2011  Total Award Amount: $2,660,000

Piero Verro, M.D. - Project 1 PI
Institution: University of California, Davis
Project Title: Genomics and Genetics of TIAs and Stroke in Humans. Project #1: Genomic Prediction of Causes of Ischemic Stroke

S. Claiborne Johnston, M.D., Ph.D.  
Institution: University of California, San Francisco
Project Title: Genomics and Genetics of TIAs and Stroke in Humans. Project #2:Genomic Diagnosis and Assessment of Causes of TIAs
 

Massachusetts General Hospital
Eng Lo, Ph.D.  
Project Title: Matrix metalloproteinases in stroke recovery
Award start date: 7/1/2005  Award End Date: 6/30/2009  Total Award Amount: $400,000

Oregon Health & Science University, Portland
Stephen Back, M.D., Ph.D.  
Project Title: Role of Extracellular Matrix in Hypoxic-ischemic Perinatal White Matter Injury
Award start date: 7/1/2005  Award End Date: 6/30/2009  Total Award Amount: $400,000

Oregon Health &Science University, Portland
Patricia Hurn, Ph.D.    
Project Title: Sex Specific Ischemic Cell Signaling
Award start date: 7/1/2005  Award End Date: 12/30/2009  Total Award Amount: $400,000

University of Cincinnati
Stephen Page, Ph.D.    
Project Title: Electrical stimulation dosing and neural mechanisms of recovery in subacute stroke
Award start date: 7/1/2005  Award End Date: 6/30/2009  Total Award Amount: $397,464

University of Iowa, Iowa City
Frank Faraci, Ph.D.    
Project Title: Role of Oxidative Stress in Cerebral Circulation During Aging
Award start date: 7/1/2005  Award End Date: 6/30/2009  Total Award Amount: $400,000

University of Kentucky
William Maragos, M.D., Ph.D.
Project Title: Targeted mitochondrial uncoupling in focal cerebral ischemia
Award start date: 7/1/2005  Award End Date: 6/30/2009  Total Award Amount: $400,000

Wayne State University
Kenneth Maises, M.D.   
Project Title: Mobilizing the Wnt Gene Against Oxidative Stress During Stroke
Award start date: 7/1/2005  Award End Date: 6/30/2009  Total Award Amount: $400,000

Weill Medical College of Cornell University
Susan Vannucci, Ph.D.  
Project Title: Substrate Intervention and Ischemic Neuroprotection in Developing Brain
Award start date: 7/1/2005  Award End Date: 6/30/2009  Total Award Amount: $400,000
 

Baylor College of Medicine, Houston
Robert Bryan, Ph.D.
Project Title: Endothelium-Derived Hyperpolarizing Factor in Cerebral Vessels Involves Arachidonic Acid
Award start date: 1/1/2002  Award End Date: 12/31/2005  Total Award Amount: $400,000

Henry Ford Health Systems
Robert Knight, D.Sc.
Project Title: Evaluation of Blood Barrier Disruption in Acute Cerebral Ischemia
Award start date: 1/1/2002  Award End Date: 12/31/2005  Total Award Amount: $398,660

Johns Hopkins University
Rafael Tamargo, M.D.
Project Title: The Inflammatory Hypothesis of Cerebral Vasospasm: Leukocytes as Mediators and Therapeutic Targets
Award start date: 1/1/2002  Award End Date: 12/31/2005  Total Award Amount: $400,000

Nemours Children's Clinic, Wilmington
N Carolyn Schanen, M.D., Ph.D.
Project Title: Determining the Role of Notch3 in Vascular Smooth Muscle Cell Homeostasis
Award start date: 1/1/2002  Award End Date: 12/31/2005  Total Award Amount: $400,000|

Stanford University School of Medicine
Pak Chan, Ph.D.
Project Title: Oxidative Stress and Metalloproteinases in Blood- Brain Barrier Injury in the Ischemic Brain
Award start date: 1/1/2002  Award End Date: 12/31/2005  Total Award Amount: $400,000

University of Chicago Hospitals
Robert Macdonald, M.D., Ph.D.
Project Title: Role of Potassium Channels in Cerebral Vasospasm
Award start date: 1/1/2002  Award End Date: 12/31/2005  Total Award Amount: $400,000

|Wake Forest University Baptist Medical Center
David Busija, Ph.D.
Project Title: Effects of Insulin Resistance on Cerebrovascular Responsiveness and Stroke in Rats
Award start date: 1/1/2002  Award End Date: 12/31/2005  Total Award Amount: $400,000
 

Barrow Neurological Institute, Phoenix
Eric Johnson, Ph.D.
Project Title: Genetics of Neurovascular Disease
Award start date: 1/1/2001  Award End Date: 12/31/2004  Total Award Amount: $400,000

Brigham and Women's Hospital
James Liao, M.D.
Project Title: Rho-Induced Cytoskeletal Regulation of Endothelial Nitric Oxide Synthase
Award start date: 1/1/2001  Award End Date: 12/31/2004  Total Award Amount: $400,000

Mayo Clinic, Rochster
Irene Meissner, M.D.
Project Title: Metabolic and Inflammatory Mechanisms in Atherosclerosis
Award start date: 1/1/2001  Award End Date: 12/31/2004  Total Award Amount: $400,000

|Medical University of South Carolina
Ling Wei, M.D.
Project Title: Effects of bFGF and VEGF on Angiogenesis and Long-term Functional Recovery after Ministroke in the Mouse
Award start date: 1/1/2001  Award End Date: 12/31/2004  Total Award Amount: $400,000

Medical University of South Carolina
Shan Yu, MD, Ph.D.
Project Title: Potassium Channel Modulation in Apoptosis and Effects of Potassium Channel Blockers on Ischemic Cell Death
Award start date: 1/1/2001  Award End Date: 12/31/2004  Total Award Amount: $400,000

University of California, Los Angeles
Chelsea Kidwell, M.D.
Project Title: Characterizing the Ischemic Penumbra and Response to Intra-arterial Thrombolytic Therapy in Humans Using Diffusion/Per…
Award start date: 1/1/2001  Award End Date: 12/31/2004  Total Award Amount: $400,000

University of Chicago Hospitals
Richard Kraig, Ph.D., M.D.
Project Title: Cyclooxygenase, Interleukin-1 & Spreading Depression-Induced Modulation of Excitoxic Brain Injury
Award start date: 1/1/2001  Award End Date: 12/31/2004  Total Award Amount: $400,000

University of Iowa, Iowa City
Steven Lentz, M.D., Ph.D.
Project Title: Methionine Metabolism, Cerebral Vascular Dysfunction, and Thrombosis
Award start date: 1/1/2001  Award End Date: 12/31/2004  Total Award Amount: $400,000

University of Kansas Medical Center
Randolph Nudo, Ph.D.
Project Title: Neural Bases for Effects of Amphetamine on Motor Recovery After Stroke
Award start date: 1/1/2001  Award End Date: 12/31/2004  Total Award Amount: $400,000

University of Pennsylvania
Vladimir Muzykantov, M.D., Ph.D.
Project Title: Thromboprophylaxis for Cerebral Microembolism
Award start date: 1/1/2001  Award End Date: 12/31/2004  Total Award Amount: $400,000
 

Allegheny-Singer Research Institute
Stephen Jones, Ph.D.  
Project Title: Cerebral Blood Flow Regulation in Hypotension and Ischemia
Award start date: 1/1/2000  Award End Date: 12/31/2003  Total Award Amount: $400,000

Duke University
Douglas Marchuk, Ph.D.
Project Title: Molecular Genetic Analysis of Cerebral Cavernous Malformations
Award start date: 1/1/2000  Award End Date: 12/31/2003  Total Award Amount: $400,000

Indiana University, Bloomington
Zao Xu, M.D., Ph.D.
Project Title: Mechanisms of Neuronal Injury in Hippocampus After Cerebral Ischemia
Award start date: 1/1/2000  Award End Date: 12/31/2003  Total Award Amount: $388,188

Louisiana State University, Shreveport
John (He) Zhang, M.D., Ph.D.  
Project Title: Signal Transduction in Cerebral Vasospasm
Award start date: 1/1/2000  Award End Date: 12/31/2003  Total Award Amount: $400,000

Mayo Medical School, Rochester
Zvonimir Katusic, M.D., Ph.D.  
Project Title: Expression and Function of Recombinant Nitric Oxide Synthase Gene in Human Cerebral Arteries
Award start date: 1/1/2000  Award End Date: 12/31/2003  Total Award Amount: $389,385

Stanford University School of Medicine
Rona Gifford, Ph.D., M.D.
Project Title: Brain Cell Vulnerability to Cerebral Ischemia and Acidosis-The Sodium Bicarbonate Cotransporter
Award start date: 7/1/2000  Award End Date: 6/30/2004  Total Award Amount: $400,000

University of Cincinnati
Frank Sharp, M.D.
Project Title: Role of Hypoxia Inducible Factor in Stroke
Award start date: 1/1/2000  Award End Date: 12/31/2003  Total Award Amount: $400,000

University of Maryland, Baltimore
J Marc Simard, M.D., Ph.D.
Project Title: Regulation of Cerebrovascular Smooth Muscle Gap Junction Channels by Endothelium and Second Messengers
Award start date: 1/1/2000  Award End Date: 12/31/2003  Total Award Amount: $383,341

University of Pennsylvania
Mark Kahn, M.D.
Project Title: Molecular Identification and Characterization of the Signaling Receptor for Collagen on Human Platelets
Award start date: 1/1/2000  Award End Date: 12/31/2003  Total Award Amount: $400,000

Washington University School of Medicine
Colin Derdeyn, M.D.
Project Title: The Effect of HMG-CoA Reductase Inhibitors on CBF in Humans
Award start date: 1/1/2000  Award End Date: 12/31/2003  Total Award Amount: $399,422

Yale University
Pasko Rakic, M.D., Ph.D.
Project Title: The Role of Jun Kinase and Caspase in Neuronal Apoptosis Induced by Ischemia-Hypoxia
Award start date: 1/1/2000  Award End Date: 12/31/2003  Total Award Amount: $379,328