Top Scientific Advances in Heart Failure and Transplantation

Updated:Jan 25,2013

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The mission of the Council on Clinical Cardiology’s Heart Failure & Transplantation Committee is to serve as the American Heart Association’s panel of experts on heart failure and cardiac transplantation. Mission goals are shown below:

  • Address issues as they arise related to the medical aspects of both heart failure and cardiac transplantation.
  • Promote research and educational activities that may decrease morbidity and mortality from heart failure.
  • Maintain current guidelines for the management of cardiac transplant donors and recipients.
  • Serve as a resource in all areas of heart failure and cardiac transplantation and to provide the Executive Committee and the AHA with regular opinions concerning developments in this field.
  • Integrate information between scientists and the public about the importance of clinical and basic science research, the application of knowledge in the clinical arena, and the fostering of inquiry to improve the prevention and therapy of heart failure and promote issues of awareness concerning organ donation.

Eldrin F. Lewis, MD, MPH
Chair, Heart Failure & Transplantation Committee
Associate Physician, Brigham and Women's Hospital
Assistant Professor of Medicine, Harvard Medical School


Adrian F. Hernandez, MD, MHS
Vice Chair, Heart Failure & Transplantation Committee
Associate Professor of Medicine, Duke University School of Medicine

The following are some of the top research advances related to Heart Failure and Transplantation. 

Top Scientific Advances in Heart Failure and Transplantation

Animal Models of Heart Failure: A Scientific Statement from American Heart Association.
Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman HA, Kass DA, Molkentin JD, Sussman MA, and Koch W. Circulation Research. 2012; RES.0b013e3182582523 published online before print May 17 2012, doi:10.1161/RES.0b013e3182582523.
ACCF/AHA/AMA-PCPI 2011 Performance Measures for Adults With Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures and the American Medical Association–Physician Consortium for Performance Improvement.
Writing Committee Members; Bonow RO, Ganiats TG, Beam CT, Blake K, Casey DE, Goodlin SJ, Grady KL, Hundley RF, Jessup M, Lynn TE, Masoudi FA, Nilasena D, Piña IL, Rockswold PD, Sadwin LB, Sikkema JD, Sincak CA, Spertus J, Torcson PJ, Torres E, Williams MV, Wong JB. Circulation. 2012; 125: 2382-2401. Published online before print April 23, 2012, doi: 10.1161/CIR.0b013e3182507bec.
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Decision Making in Advanced Heart Failure: A Scientific Statement From the American Heart Association.
Allen LA, Stevenson LW, Grady KL, Goldstein NE, Matlock DD, Arnold RM, Cook NR, Felker GM, Francis GS, Hauptman PJ, Havranek EP, Krumholz HM, Mancini D, Riegel B, Spertus JA, FAHA on behalf of the American Heart Association Council on Quality of Care and Outcomes Research Council on Cardiovascular and Stroke Nursing Council on Clinical Cardiology Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia. Circulation. 2012; 125: 1928-1952. Published online before print March 5, 2012, doi: 10.1161/?CIR.0b013e31824f2173.
Truncations of Titin Causing Dilated Cardiomyopathy.
Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE. N Engl J Med. 2012 Feb 16;366(7):619-28.
Indications for Cardiac Resynchronization Therapy: 2011 Update From the Heart Failure Society of America Guideline Committee.
Stevenson WG, Hernandez AF, Carson PE, Fang JC, Katz SD, Spertus JA, Sweitzer NK, Tang WH, Albert NM, Butler J, Westlake Canary CA, Collins SP, Colvin-Adams M, Ezekowitz JA, Givertz MM, Hershberger RE, Rogers JG, Teerlink JR, Walsh MN, Stough WG, Starling RC; Heart Failure Society of America Guideline Committee. J Card Fail. 2012 Feb;18(2):94-106.
Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm.
Homma S, Thompson JL, Pullicino PM, Levin B, Freudenberger RS, Teerlink JR, Ammon SE, Graham S, Sacco RL, Mann DL, Mohr JP, Massie BM, Labovitz AJ, Anker SD, Lok DJ, Ponikowski P, Estol CJ, Lip GY, Di Tullio MR, Sanford AR, Mejia V, Gabriel AP, del Valle ML, Buchsbaum R; WARCEF Investigators. N Engl J Med. 2012 May 17;366(20):1859-69. Epub 2012 May 2.
Two-Year Outcomes after Transcatheter or Surgical Aortic-Valve Replacement.
Kodali SK, Williams MR, Smith CR, Svensson LG, Webb JG, Makkar RR, Fontana GP, Dewey TM, Thourani VH, Pichard AD, Fischbein M, Szeto WY, Lim S, Greason KL, Teirstein PS, Malaisrie SC, Douglas PS, Hahn RT, Whisenant B, Zajarias A, Wang D, Akin JJ, Anderson WN, Leon MB; PARTNER Trial Investigators. N Engl J Med. 2012 May 3;366(18):1686-95. Epub 2012 Mar 26.
2012 ACCF/AATS/SCAI/STS Expert Consensus Document on Transcatheter Aortic Valve Replacement.
Holmes DR Jr, Mack MJ, Kaul S, Agnihotri A, Alexander KP, Bailey SR, Calhoon JH, Carabello BA, Desai MY, Edwards FH, Francis GS, Gardner TJ, Kappetein AP, Linderbaum JA, Mukherjee C, Mukherjee D, Otto CM, Ruiz CE, Sacco RL, Smith D, Thomas JD. J Am Coll Cardiol. 2012 Mar 27;59(13):1200-54. Epub 2012 Jan 31.
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2010 Focused Update of ESC guidelines on device therapy in heart failure: An update of the 2008 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC guidelines for cardiac and resynchronization therapy Developed with the special contribution of the Heart Failure Association and the European Heart Rhythm Association.
Authors/Task Force Members, Dickstein K, Vardas PE, Auricchio A, Daubert JC, Linde C, McMurray J, Ponikowski P, Priori SG, Sutton R, van Veldhuisen DJ; ESC Committee for Practice Guidelines (CPG), Vahanian A, Auricchio A, Bax J, Ceconi C, Dean V, Filippatos G, Funck-Brentano C, Hobbs R, Kearney P, McDonagh T, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Vardas P, Widimsky P; Document Reviewers, Tendera M, Anker SD, Blanc JJ, Gasparini M, Hoes AW, Israel CW, Kalarus Z, Merkely B, Swedberg K, Camm AJ. Eur Heart J. 2010 Nov;31(21):2677-87. Epub 2010 Aug 27. 
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