Top Advances in Epidemiology and Prevention for 2011

Updated:May 15,2015
 

The Council on Epidemiology and Prevention (EPI)  focuses on population-based approaches to preventing cardiovascular diseases. The mission of the AHA Council on Epidemiology and Prevention is to lead the discovery and translation of science related to the distribution and determinants of cardiovascular disease, with an emphasis on population approaches to prevent cardiovascular disease and improve cardiovascular health.
 
1Improving cardiovascular health at population level: 39 community cluster randomised trial of Cardiovascular Health Awareness Program (CHAP).
Kaczorowski J et al. Improving Cardiovascular Health at population level: 39 community cluster randomized trial of Cardiovascular Health Awareness Program. BMJ 2011; 342:d442.
Abstract

“This community cluster randomized trial of a collaborative, multi-pronged, community-based health promotion and prevention program reduced cardiovascular morbidity at the population level, including a 9% reduction in composite endpoint hospital admissions for acute myocardial infarction, stroke, and congestive heart failure. These results are an important step forward for community-based cardiovascular health promotion programs.” 
  
-- Chris O’Donnell, MD, MPH, FAHA, Chair, Epidemiology and Prevention Council
 
2Predictors of coronary heart disease events among asymptomatic persons with low low-density lipoprotein cholesterol MESA (Multi-Ethnic Study of Atherosclerosis).
Blankstein R et al. Predictors of coronary heart disease events among asymptomatic persons with low low-density lipoprotein cholesterol MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol. 2011 Jul 19;58(4):364-74.
Abstract

“This paper provides evidence that the major risk factors for CVD are important even in people with low LDL-C.  A low LDL-C is not a free pass or get-out-of-jail-free card when it comes to heart disease and stroke.” 
  
-- David C. Goff, MD, PhD, FAHA, FACP, Vice Chair, Epidemiology and Prevention Council
 
3Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Ehret GB et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11;478(7367):103-9.
Abstract

“This study identified genetic loci related to blood pressure and linked these via a genetic risk score, to the risk of cardiac dysfunction, stroke and myocardial infarction. The findings form the basis for future studies to develop novel therapeutics for cardiovascular disease and stroke prevention.” 
   
-- Mary Cushman, MD, MSc, FAHA, Immediate Past Chair, Epidemiology and Prevention Council
4Metabolite profiles and the risk of developing diabetes.
Wang TJ et al. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011;17(4):448-53.
Abstract

“A powerful example of the promises of metabolomic profiling to derive new biomarkers for CVD-related traits.  The findings underscore the key role amino acids have in predicting diabetes.” 
   
-- Erik Ingelsson, MD, PhD, International Member-at-Large
   
5Use of a DASH food group score to predict excess weight gain in adolescent girls in the National Growth and Health Study.
Berz JPB et al. Use of a DASH Food Group Score to Predict Excess Weight Gain in Adolescent Girls in the National Growth and Health Study. Arch Pediatrics and Adolescent Med. 2011;165(6):540-46.
Abstract

bild_Diane75x75“In this longitudinal study, adolescent girls whose diet more closely resembled DASH gained less weight over 10 years. The biggest predictors of a healthy BMI were fruit consumption and having a low-fat dairy diet.” 
   
-- Diane Bild, MD, MPH, FAHA, NHLBI/NIH Liaison

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