Science News from Vascular Discovery 2018

Vascular Discovery: From Genes to Medicine
Scientific Sessions 2018

(Formerly ATVB|PVD Scientific Sessions)

May 10 – 12, 2018
Hilton San Francisco Union Square | San Francisco, Calif.

In association with: Arteriosclerosis, Thrombosis and Vascular Biology Council
Peripheral Vascular Disease Council | Genomics & Precision Medicine Council (Formerly FGTB)

This is where you'll find exclusive science content from Vascular Discovery 2018 (formerly ATVB|PVD). For previous years' coverage, check our archive page.

Science from Thursday, May 10

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Nancy R. Webb and Kiran Musunuru highlight the science presented in the Plenary Session on Precision Medicine at Vascular Discovery 2018. One much-discussed question for this session: what is the definition of precision medicine?
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Lars Maegdefessel, vice chair of Vascular Discovery 2018 and moderator Ngan Huang interview Stephen Quake about how his genomic work might impact cardiovascular medicine.
Alecia Blaszczak | The Ohio State University, Columbus, OH, at Vascular Discovery 2018.

The Impact of MHCII Loss in Myeloid Cells and Adipocytes on Atherosclerosis and Liver Fat Accumulation
Alecia Blaszczak | The Ohio State University, Columbus, OH

  • RESULTS: Adipocytes play an important role in adipose tissue inflammation and obesity-related complications by acting as antigens in diet-induced obesity.
  • Abstract for Blaszczak

Aliia Fatkhullina | Fox Chase Cancer Center, Philadelphia, PA, at Vascular Discovery 2018.

An IL23-IL22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-induced Atherosclerosis
Aliia Fatkhullina | Fox Chase Cancer Center, Philadelphia, PA

  • RESULTS: IL22 — a key regulator of pro-atherogenic intestinal microbes and inflammation — may offer protection from diet-induced atherosclerosis.
  • Abstract for Fatkhullina

Valentina Paloschi | Technical University Munich, Munich, Germany, at Vascular Discovery 2018.

Aorta-on-a-chip: a Tool to Gain Molecular and Translational Insight Into Vascular Diseases
Valentina Paloschi | Technical University Munich, Munich, Germany

  • RESULTS: Aorta-on-a-chip, an in vitro model of the human aorta, offers a three-dimensional look at how endothelial cells and the extracellular matrix responds in vivo to pro-atherosclerotic influences.
  • Abstract for Paloschi
Kenneth M. Brinkhous Young Investigator Prize in Thrombosis Finalists

Robert A Campbell | University of Utah, Salt Lake Cty, UT, at Vascular Discovery 2018.

WINNER Interferon-induced Transmembrane 3 (IFITM3) on Megakaryocytes and Platelets Regulates Fibrinogen Endocytosis and Thrombosis During Inflammation
Robert A Campbell | University of Utah, Salt Lake City, UT


Leonard Edelstein | Thomas Jefferson University, Philadelphia, PA, at Vascular Discovery 2018.

PAR4 Ala120Thr Variant Alters PAR4 Desensitization, Sensitivity to Platelet Antagonists and Risk of Large Vessel Stroke
Leonard Edelstein | Thomas Jefferson University, Philadelphia, PA


Trevor P Fidler |Columbia University, New York, NY, at Vascular Discovery 2018.

Glucose Metabolism is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes Mellitus
Trevor P Fidler |Columbia University, New York, NY


Milka Koupenova | University of Massachusetts Medical School, Worcester, MA, at Vascular Discovery 2018.

Platelet TLRs Mediate Complement C3 Release During the Initial Neutrophil Response to Pathogens
Milka Koupenova | University of Massachusetts Medical School, Worcester, MA




Mentor of Women Award

Kathryn J. Moore, PhD, FAHA

Congratulations to Kathryn J. Moore, PhD, FAHA, winner of the 2018 Mentor of Women Award, which was presented at the Mentor of Women Luncheon on Thursday. The award is sponsored by the ATVB Women’s Leadership Committee, and is presented to a member of the ATVB Council who has shown exceptional support of the careers of women in the fields of arteriosclerosis, thrombosis and vascular biology on an individual and global basis through mentoring and advocacy.

Moore is a professor of Cardiology and Cell Biology at New York University School of Medicine, specializing in molecular pathogenesis of cardiometabolic diseases.



Irvine H. Page Young Investigator Research Award Finalists

Jose J Fuster | University of Virginia School of Medicine, Charlottesville, VA, at Vascular Discovery 2018.

TET2 Loss of Function-driven Clonal Hematopoiesis Promotes Age-related Vascular and Systemic Inflammation and Metabolic Dysfunction in Mice
Jose J Fuster | University of Virginia School of Medicine, Charlottesville, VA


Elizabeth J Tarling | UCLA, Los Angeles, CA, at Vascular Discovery 2018.

WINNER Anti-MicroRNA-144 Therapy Attenuates Progression and Promotes Regression of Atherosclerosis
Elizabeth J Tarling | UCLA, Los Angeles, CA


Hagai Tavori | Oregon Health & Science University, Portland, OR, at Vascular Discovery 2018.

Regression of Atherosclerosis Through Manipulation of Vascular Macrophages; a Novel Gene-therapy Approach
Hagai Tavori | Oregon Health & Science University, Portland, OR


Qiuyu M Zhu | Broad Institute, Cambridge, MA, at Vascular Discovery 2018.

ARHGEF26 is a Novel Genetic Risk Factor for Vascular Inflammation and Coronary Artery Disease
Qiuyu M Zhu | Broad Institute, Cambridge, MA

 

Science from Friday, May 11

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Peter Henke, Mary Cushman, and Alisa Wolberg describe a crowdsource approach to setting research priorities in thrombosis that they helped launch during Vascular Discovery 2018.
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Alisa Wolberg interviews the 2018 Brinkhous Young Investigator Prize Winner Robert Campbell about his work on interferon-induced transmembrane 3 (IFITM3), and read Campbell's abstract.
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Johnathan Smith interviews the 2018 Irvine H. Page Award Winner Elizabeth J. Tarling about her work on anti-mRNA-144 therapy, and read Tarling's abstract.
 
ATVB Journal Young Investigator Award Recipients

ATVB Journal YIA Recipients
Mireille Ouimet, PhDReheman Adili, MDLeena Panneerseelan-Bharath, PhD

Congratulations to this year's ATVB Journal Young Investigator Award Recipients! From left to right:

  • Mireille Ouimet | Ottawa Heart Institute, Ottawa, Canada, winner of the Daniel Steinberg Early Career Investigator Award in Arteriosclerosis/Lipoproteins
  • T. Reheman Adili | University of Michigan, Ann Arbor, Michigan, winner of the Karl Link Early Career Investigator Award in Thrombosis
  • Leena Panneerseelan-Bharath | Boston University, Boston, Massachusetts, winner of the Werner Risau Early Career Investigator Award in Vascular Biology

This year, more than 400 articles were submitted for consideration. Read more about each award, and find out how to you can apply for one.

A New Model of Murine Stasis Pulmonary Thromboembolism in vivo With Assessment by Noninvasive Multimodal Molecular-Structural Imaging
Chase W Kessinger | Massachusetts General Hospital/Harvard Medical School, Boston, MA

  • RESULTS: Novel model of venous stasis-induced thrombus pulmonary embolism allows in vivo study; healing status assessed by molecular-structural imaging.
  • Abstract for Kessinger

Clinical and Genetic Determinants of Varicose Veins: a Prospective, Community-Based Study of ~500,000 Individuals
Alyssa M Flores | Stanford University School of Medicine, Stanford, CA

  • RESULTS: Machine learning in a UK biobank study identified new clinical and genetic risk factors of varicose veins. The most important were Increased height and leg bioimpedence.
  • Abstract for Flores

Defining the Mechanisms of Autologous Bone Marrow Cell Therapy in Critical Limb Ischemia
Bianca Kenyon | Indiana University School of Medicine, Indianapolis, IN

  • RESULTS: First in man analyses shows that autologous concentrated bone marrow mononuclear cells (cBMNC) improves limb perfusion by formation of capillaries.
  • Abstract for Kenyon

Targeted Nanotherapy for the Treatment of Atherosclerosis
Neel A Mansukhani | Northwestern University, Chicago, IL

  • RESULTS: In the lab, targeted use of nanofibers containing a liver receptor agonist and apolipoprotein A1 reduced atherosclerotic plaques after 8 weeks.
  • Abstract for Mansukhani

Local Artery Wall Inflammation Overrides Systemic Inflammation in Diabetes-Accelerated Atherosclerosis
Jenny E Kanter | University of Washington, Seattle, WA

  • RESULTS: Study finds greater role for local artery wall inflammation than for systemic inflammation in diabetes-accelerated atherosclerosis.
  • Abstract for Kanter

Development of a Gut-microbe Targeted Non-lethal Therapeutic to Inhibit Thrombosis Potential Without Enhanced Bleeding
Adam Roberts | Cleveland Clinic Foundation, Cleveland, OH

  • RESULTS: Trimethylamine (TMA)-containing nutrients, which are common in the Western diet, produce a gut-microbe dependent metabolite, trimethylamine-N-oxide (TMAO) that increases thrombus risk. Targeting this mechanism suggests a target for therapy.
  • Abstract for Roberts

Science from Saturday, May 12

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Alan Daugherty, Editor-in-Chief of ATVB, interviews the winners of the 2018 ATVB Early Career Investigator Awards: Mireille Ouimet, Reheman Adili, and Leena Paneenseelan-Bharati.
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Aruna Pradhan interviews Amy Shah about her work on adolescent onset type 2 diabetes and its nontraditional risk factors.

Vesselin Controls Vascular Morphogenesis by Activating Small Gtpases in Endothelial Cells
Yanqing A Gong | University of Pennsylvania, Philadelphia, PA

  • RESULTS: A newly identified regulatory system for endothelial vessel formation involves vesselin.
  • Abstract for Gong

Skeletal Muscle Satellite Cells Play a Role in Regulating Angiogenesis and Arteriogenesis
Laura M Hansen | Emory University, Atlanta, GA

  • RESULTS: Ischemia upregulates cell migration and angiogenesis by skeletal muscle satellite cells.
  • Abstract for Hansen

Biophysical Properties of Nanofibrillar Scaffolds Modulate Endothelial Cell Survival in the Ischemic Hind Limb
Guang Yang | Stanford University, Palo Alto, CA

  • RESULTS: Nanofibrillar scaffolds for endothelial cells show promise for peripheral arterial disease treatment. Properties such as the nanofibril size and crosslinking may improve endothelial cell survival.
  • Abstract for Yang