Distinguished Scientists 2013 – Jonathan S. Stamler, MD, FAHA
Dr. Jonathan S. Stamler is recognized for the discovery of protein S-nitrosylation, a ubiquitous and conserved mechanism for controlling protein function and the prototypic redox-based signal. S-nitrosylation has emerged as a principal mechanism through which nitric oxide signals, and is thus recognized as central to the understanding of multiple aspects of cardiovascular physiology and disease. Dr. Stamler described the first endogenous peptide and protein S-nitrosothiols, and his and related work has demonstrated roles for S-nitrosylation in regulating ion channels, receptors, trafficking proteins and enzymes that are essential in the function of the heart and vasculature. Accordingly, dysregulated S-nitrosylation is implicated in a broad spectrum of cardiovascular diseases, including myocardial injury, heart failure, arrhythmia, pulmonary and systemic hypertension, atherosclerosis and diabetes. His research is notable for new insights into physiology, including the discovery of red blood cell-mediated vasodilation, which involves the S-nitrosylation of hemoglobin and which plays a central role in the respiratory cycle (consequently re-conceptualized as a three gas system: NO/O2/CO2). More broadly, he has discovered novel enzymatic functions for hemoglobins in bacteria, yeast, worms and mammals. Dr. Stamler is also known for discovering the enzymatic basis of nitroglycerin bioactivation, and for identifying novel enzymatic activities that govern NO bioactivity in the cardiovascular system and elsewhere, including S-nitrosylases and denitrosylases. His work anchors the development of new therapeutic approaches to disease characterized by aberrant S-nitrosylation.
Dr. Stamler has published more than 250 original articles and two books, has co-founded five companies and serves on multiple editorial and scientific advisory boards. He is the author of more than 125 patents and patent applications, and has been recognized by several prizes and awards. He attended Brandeis University, received his MD from Mount Sinai School of Medicine, completed his internship, residency and fellowships (in both Cardiovascular and Pulmonary Medicine) at Harvard Medical School and Brigham and Women’s Hospital (and affiliated VA hospital), and joined the faculty at Harvard University before spending 16 years on the faculty of Duke University. He moved to Case Western Reserve University and University Hospitals Case Medical Center in 2010.